Mechanosensitive ion channels contribute to osteoarthritis pain

Dr. Reza Sharif Naeini is an assistant professor in the department of Physiology at McGill University in Montreal, Quebec. He received his B.Sc. from the University of Montreal and his M.Sc. and Ph.D. both from McGill University. Dr. Naeini’s research area of expertise is in neurophysiology. 

Dr. Naeini’s laboratory is interested in understanding the molecular bases of mechanotransduction and the role of mechanosensory neurons in normal and pathological pain transmission. Mechanotransduction, the process through which cells convert a mechanical stimulus into an electrical signal, is of fundamental importance to physiological functions such as our senses of touch (including pain) and hearing, as well as our ability to regulate our hydromineral homeostasis (thirst), baroreflex function and myogenic tone (regulation of blood pressure). Mechanosensitive ion channels are membrane proteins responsible for most mechanotransduction processes, yet their molecular identity has not been fully resolved. Because these channels are involved in several pathologies of the nervous (chronic pain, deafness) and cardiovascular (hypertension) systems, the molecular identification of these channels, and understanding their activation properties may lead to the development of new therapeutic strategies in several clinical areas.

Lunch will be provided.
Hosted by: Dr. Geoffrey Ganter