Luis F. Queme, M.D., Ph.D.
Location
Luis Queme obtained his BS and MD from the Francisco Marroquin University in Guatemala City, Guatemala in 2007 and received his PhD in Cell Information Medicine from Nagoya University, Nagoya, Japan in 2013, after researching the role of growth factors in the development of delayed onset muscle soreness under Prof. Kazue Mizumura. He then moved to Cincinnati Ohio for a postdoctoral fellowship with Dr. Michael Jankowski at the Division of Pain Management in the Department of Anesthesia at Cincinnati Children’s Hospital where his research focused on the dual role of primary muscle afferents in controlling both nociception and the cardiovascular reflexes in response to muscle activity with the support of a postdoctoral fellowship from the American Heart Association. He later transitioned to an Instructor faculty position in the same department, focusing his research in the neuroimmune interactions that modulate the effects of stress in the development of chronic pain.
In the fall of 2022 he joined the Department of Biomedical Sciences at the University of New England College of Osteopathic Medicine as an Assistant Professor. Current NIH-funded projects focus on the role of macrophages in the development of long-lasting muscle pain using a multidisciplinary approach that combines molecular biology, ex-vivo electrophysiology and AI-driven behavioral analysis.
Credentials
Education
Post-Doctoral Training
Research
Current research
RESEARCH TOPICS
- Somatosensation
- Musculoskeletal Pain
- Chronic Pain
- Neuroimmune Interactions
- Non-neuronal regulation of Pain
- Cell-cell Communication
Selected publications
Queme LF, Jankowski MP. Chapter: Electrophysiological recordings on muscle primary sensory neurons using a muscle-nerve-dorsal root ganglion-spinal cord ex-vivo preparation. Book: Contemporary approaches to the study of pain: from molecules to neural networks. Editor: Rebecca Seal. Publisher: Springer Nature. 2022.
Queme LF, Dourson AJ, Hofmann MC, Butterfield A, Paladini RD, Jankowski MP. Disruption of Hyaluronic Acid in Skeletal Muscle Induces Decreased Voluntary Activity via Chemosensitive Muscle Afferent Sensitization in Male Mice. ENEURO. 0522-21.2022; DOI: 10.1523/ENEURO.0522-21.2022
Nagaraja S, Queme LF, Hofmann MC, Tewari SG, Jankowski MP, Reifman J. In silico Identification of Key Factors Driving the Response of Muscle Sensory Neurons to Noxious Stimuli. Front. Neurosci. 2021 Sept. DOI: 10.3389/fnins.2021.719735
Queme LF, Weyler AA, Cohen ER, Hudgins RC, Jankowski MP. A role for peripheral GDNF signaling in ischemic myalgia development. Proc Natl Acad Sci. 2020 Jan, 117 (1) 698-707; DOI: 10.1073/pnas.1910905116
Queme LF, Jankowski MP. Sex differences and mechanisms of muscle pain. Curr Opin Physiol. 2019 Oct; 11:1-6. DOI: 10.1016/j.cophys.2019.03.006 Epub 2019 Apr 2
He X, Zhang L, Queme LF, Liu X, Lu A, Waclaw RR, Dong X, Zhou W, Kidd G, Yoon SO, Buonanno A, Rubin JB, Xin M, Nave KA, Trapp BD, Jankowski MP, Lu QR. A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nat Med. 2018 Mar;24(3):338-351. DOI: 10.1038/nm.4483
Queme LF, Ross JL, Jankowski MP. Peripheral Mechanisms of Ischemic Myalgia. Front Cell Neurosci. 2017 Dec 22;11:419. DOI: 10.3389/fncel.2017.00419
Queme LF, Ross JL, Lu P, Hudgins RC and Jankowski MP. Dual modulation of nociception and cardiovascular reflexes during peripheral ischemia through P2Y1 receptor dependent sensitization of muscle afferents. J Neurosci. 2016; 36(1):19-30. DOI:10.1523/JNEUROSCI.2856-15.2016
Ross JL, Queme LF, Shank AT, Hudgins RC, Jankowski MP. Sensitization of group III and IV muscle afferents in the mouse after ischemia and reperfusion injury. J Pain. 2014; 15(12):1257-70. DOI:10.1016/j.jpain.2014.09.003
Murase S, Terazawa E, Hirate K, Yamanaka H, Kanda H, Noguchi K, Ota H, Queme F, Taguchi T, Mizumura K. Upregulated Glial Cell Line-derived Neurotrophic Factor Through Cyclooxygenase-2 Activation in the Muscle is Required for Mechanical Hyperalgesia After Exercise in Rats. J Physiol. 2013 Jun 15;591(12):3035-48. DOI: 10.1113/jphysiol.2012.249235
Murase S, Terazawa E, Queme F, Ota H, Matsuda T, Hirate K, Kozaki Y, Katanosaka K, Taguchi T, Urai H, Mizumura K. Bradykinin and Nerve Growth Factor Play Pivotal Roles in Muscular Mechanical Hyperalgesia After Exercise (Delayed-onset Muscle Soreness). J Neurosci. 2010 Mar 10;30(10):3752-61. DOI: 10.1523/JNEUROSCI.3803-09.2010
Research interests
Peripheral mechanisms of the transition from acute to chronic pain, effect of stress in the development of muscle pain, Peripheral neuroimmune interactions.