Recent Publications
Whitaker EE, Mecum NE, Cott RC, Goode DJ. Expression of MHC II in DRG neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice. PLoS One. 2024 Feb 8;19(2):e0298396. doi: 10.1371/journal.pone.0298396. PMID: 38330029; PMCID: PMC10852343.
Goode DJ. Immunotherapy, a new approach for the treatment of human pain. Pain. 2024 Apr 1;165(4):725-726. doi: 10.1097/j.pain.0000000000003107. Epub 2023 Nov 16. PMID: 37975869.
Fitzsimons LA, Tasouri E, Willaredt MA, Stetson D, Gojak C, Kirsch J, Gardner HAR, Gorgas K, Tucker KL. Primary cilia are critical for tracheoesophageal septation. Dev Dyn. 2024 Mar;253(3):312-332. doi: 10.1002/dvdy.660. Epub 2023 Sep 30. PMID: 37776236; PMCID: PMC10922539.
Fitzsimons LA, Staurengo-Ferrari L, Bogen O, Araldi D, Bonet IJM, Jordan EE, Levine JD, Tucker KL. The Primary Cilium and its Hedgehog Signaling in Nociceptors Contribute to Inflammatory and Neuropathic Pain. Res Sq [Preprint]. 2024 Feb 26:rs.3.rs-3812442. doi: 10.21203/rs.3.rs-3812442/v1. PMID: 38464172; PMCID: PMC10925437.
Remember to acknowledge the COBRE Behavioral Core and the financial support provided by NIGMS grant number P30GM145497 in manuscripts, grants, and presentations that include our work.
Past Publications
Robbins A, Kurose M, Winterson BJ, Meng ID. Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. Invest Ophthalmol Vis Sci. 2012 Oct 9;53(11):7034-42. doi: 10.1167/iovs.12-10025. PMID: 22952122; PMCID: PMC3471555.
Cao L, Beaulac H, Eurich A. Differential lumbar spinal cord responses among wild type, CD4 knockout, and CD40 knockout mice in spinal nerve L5 transection-induced neuropathic pain. Mol Pain. 2012 Dec 18;8:88. doi: 10.1186/1744-8069-8-88. PMID: 23249743; PMCID: PMC3545955.
Kurose M, Meng ID. Corneal dry-responsive neurons in the spinal trigeminal nucleus respond to innocuous cooling in the rat. J Neurophysiol. 2013 May;109(10):2517-22. doi: 10.1152/jn.00889.2012. Epub 2013 Feb 27. PMID: 23446686; PMCID: PMC3653041.
Kurose M, Meng ID. Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells. J Neurophysiol. 2013 Jul;110(2):495-504. doi: 10.1152/jn.00222.2013. Epub 2013 May 1. PMID: 23636717; PMCID: PMC3727064.
Meng ID, Kurose M. The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Exp Eye Res. 2013 Dec;117:79-87. doi: 10.1016/j.exer.2013.08.011. Epub 2013 Aug 28. PMID: 23994439; PMCID: PMC3989072.
Largent-Milnes TM, Brookshire SW, Skinner DP Jr, Hanlon KE, Giuvelis D, Yamamoto T, Davis P, Campos CR, Nair P, Deekonda S, Bilsky EJ, Porreca F, Hruby VJ, Vanderah TW. Building a better analgesic: multifunctional compounds that address injury-induced pathology to enhance analgesic efficacy while eliminating unwanted side effects. J Pharmacol Exp Ther. 2013 Oct;347(1):7-19. doi: 10.1124/jpet.113.205245. Epub 2013 Jul 16. PMID: 23860305; PMCID: PMC3781412.
Burman MA, Simmons CA, Hughes M, Lei L. Developing and validating trace fear conditioning protocols in C57BL/6 mice. J Neurosci Methods. 2014 Jan 30;222:111-7. doi: 10.1016/j.jneumeth.2013.11.005. Epub 2013 Nov 20. PMID: 24269252; PMCID: PMC3927557.
Cao L, Butler MB. Involvement of microglial CD40 in murine retrovirus-induced peripheral neuropathy. J Neuroimmunol. 2013 Aug 15;261(1-2):37-43. doi: 10.1016/j.jneuroim.2013.04.023. Epub 2013 May 28. PMID: 23726765; PMCID: PMC3729793.
Parlato R, Mandl C, Hölzl-Wenig G, Liss B, Tucker KL, Ciccolini F. Regulation of proliferation and histone acetylation in embryonic neural precursors by CREB/CREM signaling. Neurogenesis (Austin). 2014 Nov 26;1(1):e970883. doi: 10.4161/23262125.2014.970883. PMID: 27504469; PMCID: PMC4973597.
Burman MA, Erickson KJ, Deal AL, Jacobson RE. Contextual and auditory fear conditioning continue to emerge during the periweaning period in rats. PLoS One. 2014 Jun 30;9(6):e100807. doi: 10.1371/journal.pone.0100807. PMID: 24977415; PMCID: PMC4076234.
Deal AL, Erickson KJ, Bilsky EJ, Hillman SJ, Burman MA. K-12 Neuroscience Education Outreach Program: Interactive Activities for Educating Students about Neuroscience. J Undergrad Neurosci Educ. 2014 Oct 15;13(1):A8-A20. PMID: 25565921; PMCID: PMC4281050.
Meng ID, Barton ST, Mecum NE, Kurose M. Corneal sensitivity following lacrimal gland excision in the rat. Invest Ophthalmol Vis Sci. 2015 May;56(5):3347-54. doi: 10.1167/iovs.15-16717. PMID: 26024120; PMCID: PMC4453983.
Stevenson GW, Luginbuhl A, Dunbar C, LaVigne J, Dutra J, Atherton P, Bell B, Cone K, Giuvelis D, Polt R, Streicher JM, Bilsky EJ. The mixed-action delta/mu opioid agonist MMP-2200 does not produce conditioned place preference but does maintain drug self-administration in rats, and induces in vitro markers of tolerance and dependence. Pharmacol Biochem Behav. 2015 May;132:49-55. doi: 10.1016/j.pbb.2015.02.022. Epub 2015 Feb 28. PMID: 25735493; PMCID: PMC4552603.
Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. Structural Requirements for CNS Active Opioid Glycopeptides. J Med Chem. 2015 Aug 13;58(15):5728-41. doi: 10.1021/acs.jmedchem.5b00014. Epub 2015 Jul 23. PMID: 26125201.
Warner E, Krivitsky R, Cone K, Atherton P, Pitre T, Lanpher J, Giuvelis D, Bergquist I, King T, Bilsky EJ, Stevenson GW. Evaluation of a Postoperative Pain-Like State on Motivated Behavior in Rats: Effects of Plantar Incision on Progressive-Ratio Food-Maintained Responding. Drug Dev Res. 2015 Dec;76(8):432-41. doi: 10.1002/ddr.21284. Epub 2015 Oct 23. PMID: 26494422; PMCID: PMC4715615.
Gazea M, Tasouri E, Tolve M, Bosch V, Kabanova A, Gojak C, Kurtulmus B, Novikov O, Spatz J, Pereira G, Hübner W, Brodski C, Tucker KL, Blaess S. Primary cilia are critical for Sonic hedgehog-mediated dopaminergic neurogenesis in the embryonic midbrain. Dev Biol. 2016 Jan 1;409(1):55-71. doi: 10.1016/j.ydbio.2015.10.033. Epub 2015 Nov 2. PMID: 26542012; PMCID: PMC5873949.
Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons. Pain. 2016 Jan;157(1):166-173. doi: 10.1097/j.pain.0000000000000344. PMID: 26335909; PMCID: PMC4829402.
Mecum NE, Russell R, Lee J, Sullivan C, Meng ID. Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain. Invest Ophthalmol Vis Sci. 2021 Nov 1;62(14):15. doi: 10.1167/iovs.62.14.15. PMID: 34787642; PMCID: PMC8606841.
Gazea M, Tasouri E, Heigl T, Bosch V, Tucker KL, Blaess S. Definition of a critical spatiotemporal window within which primary cilia control midbrain dopaminergic neurogenesis. Neurogenesis (Austin). 2016 Oct 20;3(1):e1248206. doi: 10.1080/23262133.2016.1248206. PMID: 28090543; PMCID: PMC5129902.
Burman MA, Szolusha K, Bind R, Kerney K, Boger DL, Bilsky EJ. FAAH inhibitor OL-135 disrupts contextual, but not auditory, fear conditioning in rats. Behav Brain Res. 2016 Jul 15;308:1-5. doi: 10.1016/j.bbr.2016.04.014. Epub 2016 Apr 13. PMID: 27083303; PMCID: PMC4877211.
Hitomi S, Kross K, Kurose M, Porreca F, Meng ID. Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla. Cephalalgia. 2017 Apr;37(5):407-417. doi: 10.1177/0333102416648655. Epub 2016 May 6. PMID: 27155000.
Havelin J, Imbert I, Sukhtankar D, Remeniuk B, Pelletier I, Gentry J, Okun A, Tiutan T, Porreca F, King TE. Mediation of Movement-Induced Breakthrough Cancer Pain by IB4-Binding Nociceptors in Rats. J Neurosci. 2017 May 17;37(20):5111-5122. doi: 10.1523/JNEUROSCI.1212-16.2017. Epub 2017 Apr 24. PMID: 28438966; PMCID: PMC5444195.
Davis SM, Rice M, Rudlong J, Eaton V, King T, Burman MA. Neonatal pain and stress disrupts later-life pavlovian fear conditioning and sensory function in rats: Evidence for a two-hit model. Dev Psychobiol. 2018 Jul;60(5):520-533. doi: 10.1002/dev.21632. Epub 2018 May 10. PMID: 29749116; PMCID: PMC6139181.
Wakley AA, Leeming R, Malon J, Arabatzis TJ, Yuen Koh W, Cao L. Contribution of CD137L to Sensory Hypersensitivity in a Murine Model of Neuropathic Pain. eNeuro. 2018 Nov 8;5(5):ENEURO.0218-18.2018. doi: 10.1523/ENEURO.0218-18.2018. PMID: 30417077; PMCID: PMC6223109.
Rieder CA, Rieder J, Sannajust S, Goode DJ, Geguchadze R, Relich RF, Molliver DC, King TE, Vaughn J, May M. A Novel Mechanism for Zika Virus Host-Cell Binding. Viruses. 2019 Nov 28;11(12):1101. doi: 10.3390/v11121101. PMID: 31795144; PMCID: PMC6949893.
Meng ID, Barton ST, Goodney I, Russell R, Mecum NE. Progesterone Application to the Rat Forehead Produces Corneal Antinociception. Invest Ophthalmol Vis Sci. 2019 Apr 1;60(5):1706-1713. doi: 10.1167/iovs.18-26049. PMID: 31013343; PMCID: PMC6736375.
Hatta A, Kurose M, Sullivan C, Okamoto K, Fujii N, Yamamura K, Meng ID. Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1. J Neurophysiol. 2019 Jun 1;121(6):2191-2201. doi: 10.1152/jn.00126.2018. Epub 2019 Apr 10. PMID: 30969886; PMCID: PMC6620696.
Mecum NE, Cyr D, Malon J, Demers D, Cao L, Meng ID. Evaluation of Corneal Damage After Lacrimal Gland Excision in Male and Female Mice. Invest Ophthalmol Vis Sci. 2019 Aug 1;60(10):3264-3274. doi: 10.1167/iovs.18-26457. PMID: 31369671; PMCID: PMC6675517.
Huynh PN, Giuvelis D, Christensen S, Tucker KL, McIntosh JM. RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats. Mar Drugs. 2019 Dec 21;18(1):12. doi: 10.3390/md18010012. PMID: 31877728; PMCID: PMC7024385.
Eaton VE, Pettit S, Elkinson A, Houseknecht KL, King TE, May M. Polymicrobial abscess following ovariectomy in a mouse. BMC Vet Res. 2019 Oct 24;15(1):364. doi: 10.1186/s12917-019-2125-0. PMID: 31651316; PMCID: PMC6814026.
Mustafa R, Kreiner G, Kamińska K, Wood AJ, Kirsch J, Tucker KL, Parlato R. Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington's Disease. Front Cell Neurosci. 2019 Dec 20;13:565. doi: 10.3389/fncel.2019.00565. PMID: 31920562; PMCID: PMC6936315.
Zuke JT, Rice M, Rudlong J, Paquin T, Russo E, Burman MA. The Effects of Acute Neonatal Pain on Expression of Corticotropin-Releasing Hormone and Juvenile Anxiety in a Rodent Model. eNeuro. 2019 Oct 10;6(6):ENEURO.0162-19.2019. doi: 10.1523/ENEURO.0162-19.2019. PMID: 31601633; PMCID: PMC6860982.
Mecum NE, Demers D, Sullivan CE, Denis TE, Kalliel JR, Meng ID. Lacrimal gland excision in male and female mice causes ocular pain and anxiety-like behaviors. Sci Rep. 2020 Oct 14;10(1):17225. doi: 10.1038/s41598-020-73945-w. PMID: 33057056; PMCID: PMC7560880.
Stevenson GW, Giuvelis D, Cormier J, Cone K, Atherton P, Krivitsky R, Warner E, St Laurent B, Dutra J, Bidlack JM, Szabò L, Polt R, Bilsky EJ. Behavioral pharmacology of the mixed-action delta-selective opioid receptor agonist BBI-11008: studies on acute, inflammatory and neuropathic pain, respiration, and drug self-administration. Psychopharmacology (Berl). 2020 Apr;237(4):1195-1208. doi: 10.1007/s00213-019-05449-z. Epub 2020 Jan 7. PMID: 31912192; PMCID: PMC8106974.
Parlato R, Tucker KL. Editorial: Emerging Cellular Stress Sensors in Neurological Disorders: Closing in on the Nucleolus and the Primary Cilium. Front Cell Neurosci. 2020 Mar 20;14:64. doi: 10.3389/fncel.2020.00064. PMID: 32265665; PMCID: PMC7100531.
Fitzsimons LA, Brewer VL, Forrester J, Moran AM, Tucker KL. Noninvasive Electrocardiography in the Perinatal Mouse. J Vis Exp. 2020 Jun 12;(160). doi: 10.3791/61074. PMID: 32597855.
Davis SM, Rice M, Burman MA. Inflammatory neonatal pain disrupts maternal behavior and subsequent fear conditioning in a rodent model. Dev Psychobiol. 2020 Jan;62(1):88-98. doi: 10.1002/dev.21889. Epub 2019 Jul 3. PMID: 31270817; PMCID: PMC7238892.
Davis SM, Burman MA. Maternal separation with neonatal pain influences later-life fear conditioning and somatosenation in male and female rats. Stress. 2021 Sep;24(5):504-513. doi: 10.1080/10253890.2020.1825674. Epub 2020 Oct 12. PMID: 33043804; PMCID: PMC8039057.
Goode DJ, Molliver DC. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci. 2021 Mar 31;41(13):2883-2898. doi: 10.1523/JNEUROSCI.2368-20.2021. Epub 2021 Feb 16. PMID: 33593853; PMCID: PMC8018894.
Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV. Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Pain. 2021 Apr 1;162(4):1250-1261. doi: 10.1097/j.pain.0000000000002112. PMID: 33086288; PMCID: PMC9359086.
Mecum NE, Russell R, Lee J, Sullivan C, Meng ID. Optogenetic Inhibition of Nav1.8 Expressing Corneal Afferents Reduces Persistent Dry Eye Pain. Invest Ophthalmol Vis Sci. 2021 Nov 1;62(14):15. doi: 10.1167/iovs.62.14.15. PMID: 34787642; PMCID: PMC8606841.
Nguyen LD, Nolte LG, Tan WJT, Giuvelis D, Santos-Sacchi J, Bilsky E, Ehrlich BE. Comprehensive somatosensory and neurological phenotyping of NCS1 knockout mice. Sci Rep. 2021 Jan 27;11(1):2372. doi: 10.1038/s41598-021-81650-5. PMID: 33504822; PMCID: PMC7840744.
Beckley JT, Pajouhesh H, Luu G, Klas S, Delwig A, Monteleone D, Zhou X, Giuvelis D, Meng ID, Yeomans DC, Hunter JC, Mulcahy JV. Antinociceptive properties of an isoform-selective inhibitor of Nav1.7 derived from saxitoxin in mouse models of pain. Pain. 2021 Apr 1;162(4):1250-1261. doi: 10.1097/j.pain.0000000000002112. PMID: 33086288; PMCID: PMC9359086.
Payne E, Harrington K, Richard P, Brackin R, Davis R, Couture S, Liff J, Asmus F, Mutina E, Fisher A, Giuvelis D, Sannajust S, Rostama B, King T, Mattei LM, Lee JJ, Friedman ES, Bittinger K, May M, Stevenson GW. Effects of Vancomycin on Persistent Pain-Stimulated and Pain-Depressed Behaviors in Female Fischer Rats With or Without Voluntary Access to Running Wheels. J Pain. 2021 Nov;22(11):1530-1544. doi: 10.1016/j.jpain.2021.05.003. Epub 2021 May 21. PMID: 34029686; PMCID: PMC8578155.
Goode DJ, Molliver DC. Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia. J Neurosci. 2021 Mar 31;41(13):2883-2898. doi: 10.1523/JNEUROSCI.2368-20.2021. Epub 2021 Feb 16. PMID: 33593853; PMCID: PMC8018894.
Mustafa R, Rawas C, Mannal N, Kreiner G, Spittau B, Kamińska K, Yilmaz R, Pötschke C, Kirsch J, Liss B, Tucker KL, Parlato R. Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress. Antioxidants (Basel). 2021 Aug 13;10(8):1284. doi: 10.3390/antiox10081284. PMID: 34439532; PMCID: PMC8389284.
Davis SM, Zuke JT, Berchulski MR, Burman MA. Amygdalar Corticotropin-Releasing Factor Signaling Is Required for Later-Life Behavioral Dysfunction Following Neonatal Pain. Front Physiol. 2021 May 11;12:660792. doi: 10.3389/fphys.2021.660792. PMID: 34045975; PMCID: PMC8144524.
Goode DJ, Whitaker EE, Mecum NE. Ovariectomy increases paclitaxel-induced mechanical hypersensitivity and reduces anti-inflammatory CD4+ T cells in the dorsal root ganglion of female mice. J Neuroimmunol. 2022 Jun 15;367:577878. doi: 10.1016/j.jneuroim.2022.577878. Epub 2022 Apr 22. PMID: 35509138.
Sullivan C, Lee J, Bushey W, Demers D, Dinsdale S, Lowe K, Olmeda J, Meng ID. Evidence for a phenotypic switch in corneal afferents after lacrimal gland excision. Exp Eye Res. 2022 May;218:109005. doi: 10.1016/j.exer.2022.109005. Epub 2022 Mar 1. PMID: 35240196; PMCID: PMC9993327.
Fitzsimons LA, Brewer VL, Tucker KL. Hedgehog Morphogens Act as Growth Factors Critical to Pre- and Postnatal Cardiac Development and Maturation: How Primary Cilia Mediate Their Signal Transduction. Cells. 2022 Jun 9;11(12):1879. doi: 10.3390/cells11121879. PMID: 35741008; PMCID: PMC9221318.
Coffman JA, Burman MA, Duboué ER. Editorial: Early Life Stress and Developmental Programming of Immune and Nervous System Responsivity. Front Cell Dev Biol. 2022 Apr 14;10:897251. doi: 10.3389/fcell.2022.897251. PMID: 35493082; PMCID: PMC9047875.
Whitaker EE, Mecum NE, Cott RC, Goode DJ. Novel expression of major histocompatibility complex II in dorsal root ganglion neurons attenuates paclitaxel-induced cold hypersensitivity in male and female mice. bioRxiv [Preprint]. 2023 Sep 21:2023.03.31.535136. doi: 10.1101/2023.03.31.535136. Update in: PLoS One. 2024 Feb 8;19(2):e0298396. PMID: 37066176; PMCID: PMC10103942.
Gomez K, Santiago U, Nelson TS, Allen HN, Calderon-Rivera A, Hestehave S, Rodríguez Palma EJ, Zhou Y, Duran P, Loya-Lopez S, Zhu E, Kumar U, Shields R, Koseli E, McKiver B, Giuvelis D, Zuo W, Inyang KE, Dorame A, Chefdeville A, Ran D, Perez-Miller S, Lu Y, Liu X, Handoko, Arora PS, Patek M, Moutal A, Khanna M, Hu H, Laumet G, King T, Wang J, Damaj MI, Korczeniewska OA, Camacho CJ, Khanna R. A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain. Proc Natl Acad Sci U S A. 2023 Nov 21;120(47):e2305215120. doi: 10.1073/pnas.2305215120. Epub 2023 Nov 16. PMID: 37972067; PMCID: PMC10666126.
Grlickova-Duzevik E, Reimonn TM, Michael M, Tian T, Owyoung J, McGrath-Conwell A, Neufeld P, Mueth M, Molliver DC, Ward PJ, Harrison BJ. Members of the CUGBP Elav-like family of RNA-binding proteins are expressed in distinct populations of primary sensory neurons. J Comp Neurol. 2023 Oct;531(14):1425-1442. doi: 10.1002/cne.25520. Epub 2023 Jul 8. PMID: 37537886.
Cao L, Bean EN, Malon JT. Preparation of Primary Mixed Glial Cell Cultures from Adult Mouse Spinal Cord Tissue. Curr Protoc. 2023 Apr;3(4):e743. doi: 10.1002/cpz1.743. PMID: 37042635; PMCID: PMC10478014.